Endotoxin Reference Standard for LAL test

The Reference Standard Endotoxins RSE and BRP, produced to standardize and ensure uniformity in the LAL test, are released by USP and EP, respectively.

The typical format is 11,000–10,000 EU per vial, and they are used to set up the LAL test with any lysate lot.

Reference Endotoxins (RSE and BRP)

Composed of purified LPS
10,000 EU/vial (BRP)
11,000 EU/vial (RSE)
1 EU = 1 IU

Applications of RSE and BRP

Standardize and ensure uniformity of the LAL test
The FDA requires LAL manufacturers to establish lysate sensitivity using an assay with a series of RSE dilutions
Primary standards to determine the potency of the CSE with a specific lysate
When a reference test is needed to resolve a disagreement

Showing 1-2 of 2 item(s)

Endotoxin Reference Standard for LAL test

Reference E0150000 *

BRP, Reference Standard Endotoxin, EP

lyophilized vial with 10.000 EU

Endotoxin Reference Standard for LAL test

Reference 1235503 *

RSE, Reference Standard Endotoxin, USP

lyophilized vial with 10.000 EU

Reagents and Endotoxins for Bacterial Endotoxin Testing

The Reference Standard Endotoxins RSE and BRP are used in combination with the LAL reagent to perform the bacterial endotoxin test with all methodologies.

They can replace the Control Standard Endotoxin (CSE) provided by manufacturers paired with their specific reagent lots. Typically, RSE and BRP have a shorter shelf life once the vial is opened, but they allow the use of any lysate or LAL reagent lot, even when the paired CSE has been depleted.

LAL TEST: GEL CLOT METHOD Technical Summary n. 1

Posted in: Technical guides

July 10th 2025

A brief introduction to the LAL test and, in detail, an in-depth look at the Gel Clot method on water with a section dedicated to all the products available in the catalogue and necessary to correctly perform these operations
Read more
Interferences in the LAL test: solutions

Posted in: Technical guides

January 30th 2024

The most common sources of interference are the use of inappropriate consumables and the intrinsic characteristics of the product under examination. How to prevent and resolve interferences in the LAL test?
Read more

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Pack:

1 vial

Availability:

Delivery in 15-20 days

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